Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Mafktm1.1Jeng
Name:	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian); targeted mutation 1.1, James Douglas Engel
MGI ID:	MGI:6324506
Gene:	Mafk  Location: Chr5:139777291-139788409 bp, + strand  Genetic Position: Chr5, 78.81 cM
Alliance:	Mafktm1.1Jeng page

Germline Transmission:	Earliest citation of germline transmission: J:183645
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 2 and all of exon 3 were replaced by a cassette inserted downstream of the translational start codon and containing lacZ and floxed neo genes. RNAse protection assays were utilized to confirm the absence of transcript in homozygous mutant mice. Expression of beta-galactosidase was driven by the endogenous promoter. The loxP-flanked neomycin selection cassete was removed via cre-mediated recombination. (J:78982)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mafk Mutation:	13 strains or lines available

Original:	J:183645 Yamazaki H, et al., Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins. Mol Cell Biol. 2012 Feb;32(4):808-16
All:	2 reference(s)