Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm2.1(UBC-flpe)Ozg
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, Ozgene
MGI ID:	MGI:6297051
Synonyms:	OzFlp, Ubic-Flpe
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm2.1(UBC-flpe)Ozg page

Germline Transmission:	Earliest citation of germline transmission: J:274081
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Gt(ROSA)26Sortm2.1(UBC-flpe)Ozg expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Homolog in Mouse Note human UBC (7316) Ubc  (MGI:98889)   Mutation details: A flpe recombinase transgene, driven by the human ubiquitin C promoter, was inserted into intron 1. Downstream of the gene the transgene cassette also contains bovine growth hormone (BGH) polyadenylation signal sequence and a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed by breeding to cre allele carying mice. (J:274081)

Activity:	Tissue activity of this recombinase allele
Driver:	UBC (human) Summary of all recombinase alleles driven by UBC. Alliance human UBC gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:274081 Rashidi M, et al., CD52 inhibits Toll-like receptor activation of NF-kappaB and triggers apoptosis to suppress inflammation. Cell Death Differ. 2018 Feb;25(2):392-405
All:	2 reference(s)