Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Epas1em1Rkbk
Name:	endothelial PAS domain protein 1; endonuclease-mediated mutation 1, Richard K Bruick
MGI ID:	MGI:6276630
Synonyms:	Epas1S305M
Gene:	Epas1  Location: Chr17:87061292-87140838 bp, + strand  Genetic Position: Chr17, 56.9 cM
Alliance:	Epas1em1Rkbk page

Strain of Origin:

C57BL/6

Allele Type:    Endonuclease-mediated (Not Specified) Mutation:    Nucleotide substitutions   Mutation details: Zinc finger endonuclease-mediated mutation introduced nucleotide substitutions in exon 8 that result in the amino acid substitution of methionine for serine at position 305 (S305M) and a silent mutation. (J:268894)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epas1 Mutation:	64 strains or lines available

Original:	J:268894 Feng Z, et al., Modulation of HIF-2alpha PAS-B domain contributes to physiological responses. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13240-13245
All:	1 reference(s)