Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Cav1tm1c(KOMP)Mbp
Name:	caveolin 1, caveolae protein; targeted mutation 1c, Mouse Biology Program, UC Davis
MGI ID:	MGI:6274699
Gene:	Cav1  Location: Chr6:17306387-17341323 bp, + strand  Genetic Position: Chr6, 7.73 cM, cytoband A2
Alliance:	Cav1tm1c(KOMP)Mbp page
IMPC:	Cav1 gene page

Germline Transmission:	Earliest citation of germline transmission: J:204812
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: The L1L2_Bact_P cassette was inserted at position 17338667 of Chromosome 6 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 17339900. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:94077)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cav1 Mutation:	29 strains or lines available

Original:	J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015;
All:	2 reference(s)