Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Foxo1em2Guo
Name:	forkhead box O1; endonuclease-mediated mutation 2, Shaodong Guo
MGI ID:	MGI:6231211
Synonyms:	Foxo1-S273D
Gene:	Foxo1  Location: Chr3:52175758-52257530 bp, + strand  Genetic Position: Chr3, 23.19 cM
Alliance:	Foxo1em2Guo page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Not Applicable) Mutation:    Nucleotide substitutions   Mutation details: Endonuclease-mediated recombination replaced serine 273 with an aspartic acid (TCT to GAT, p.Ser273>Asp). (J:265936)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxo1 Mutation:	31 strains or lines available

Original:	J:265936 Wu Y, et al., Novel Mechanism of Foxo1 Phosphorylation in Glucagon Signaling in Control of Glucose Homeostasis. Diabetes. 2018 Nov;67(11):2167-2182
All:	3 reference(s)