Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gata2em1Jorc
Name:	GATA binding protein 2; endonuclease-mediated mutation 1, Jorg Cammenga
MGI ID:	MGI:6202701
Synonyms:	NRGG
Gene:	Gata2  Location: Chr6:88170873-88184014 bp, + strand  Genetic Position: Chr6, 39.2 cM
Alliance:	Gata2em1Jorc page

Strain of Origin:

NOD.Cg-Rag1tm1Mom Il2rgtm1Wjl/SzJ

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: In NRG mouse derived ES cells, exon 5 was targeted with two sgRNAs and the nickase form of Cas9, using CRISPR/Cas9 technology. Two to three targeted ES cell clones were microinjected into blastocyst-stage embryos. (J:265807)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata2 Mutation:	26 strains or lines available

Original:	J:265807 Martin Gonzalez J, et al., A new genetic tool to improve immune-compromised mouse models: Derivation and CRISPR/Cas9-mediated targeting of NRG embryonic stem cell lines. Genesis. 2018 Sep;56(9):e23238
All:	1 reference(s)