Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Airetm1Dfil
Name:	autoimmune regulator; targeted mutation 1, Dominik Filipp
MGI ID:	MGI:6200788
Synonyms:	Airefl
Gene:	Aire  Location: Chr10:77865856-77879444 bp, - strand  Genetic Position: Chr10, 39.72 cM
Alliance:	Airetm1Dfil page

Germline Transmission:	Earliest citation of germline transmission: J:258694
Parent Cell Line:	Bruce 4 (ES Cell)
Strain of Origin:	B6.Cg-Thy1a

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: The targeting vector is designed to insert a loxP-flanked PGK-NeoR/KanR cassette on one side, and a loxP site on the other side of exons 6-7. Exons 6 and 7 encode the SAND domain. (J:258694)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aire Mutation:	52 strains or lines available

Original:	J:258694 Dobes J, et al., A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire. Eur J Immunol. 2018 Mar;48(3):546-548
All:	3 reference(s)