Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stat2m1Btlr
Name:	signal transducer and activator of transcription 2; mutation 1, Bruce Beutler
MGI ID:	MGI:6200395
Synonyms:	numb
Gene:	Stat2  Location: Chr10:128106428-128128718 bp, + strand  Genetic Position: Chr10, 76.5 cM
Alliance:	Stat2m1Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) (Not Specified) Mutation:    Single point mutation   Mutation details: ENU-induced T to A transversion at base pair 128,281,065 (v38) on chromosome 10, or base pair 10,507 in the GenBank genomic region NC_000076 within intron 8 (17 base pairs from exon 9). The effect of the mutation at the cDNA and protein levels has not been examined, but the mutation is predicted to result in usage of a cryptic site in intron 8. The resulting transcript would have a 15-base pair insertion of intron 8, and would cause a predicted in-frame insertion of five aberrant amino acids after amino acid 261 of the protein. (J:265265) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stat2 Mutation:	35 strains or lines available

Original:	J:265265 Zhong X, et al., Mutagenetix entry for numb. MGI Direct Data Submission. 2018;
All:	1 reference(s)