Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Six2em1Amc
Name:	sine oculis-related homeobox 2; endonuclease-mediated mutation 1, Andrew P McMahon
MGI ID:	MGI:6197854
Synonyms:	Six2-DE, Six2deltaDE
Gene:	Six2  Location: Chr17:85991705-85995702 bp, - strand  Genetic Position: Chr17, 55.72 cM
Alliance:	Six2em1Amc page

Strain of Origin:

(C57BL/6 x SJL/J)F2

Allele Type:    Endonuclease-mediated (Hypomorph) Mutation:    Intragenic deletion   Mutation details: CRISPR/cas9 endonuclease mediated genome editing is used to delete the distal enhancer element (Chr17:85747271-85749534). (J:264647)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Six2 Mutation:	15 strains or lines available

Original:	J:264647 O'Brien LL, et al., Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studies. PLoS Genet. 2018 Jan;14(1):e1007181
All:	1 reference(s)