Summary | Mutation origin | Mutation description | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	F9em3Dlli
Name:	coagulation factor IX; endonuclease-mediated mutation 3, Dali Li
MGI ID:	MGI:6196103
Synonyms:	F9383STOP
Gene:	F9  Location: ChrX:59044824-59076119 bp, + strand  Genetic Position: ChrX, 33.5 cM, cytoband A6-A7
Alliance:	F9em3Dlli page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Hypomorph) Mutation:    Insertion   Mutation details: CRISPR/Cas9 technology generated a premature stop codon (TAG) at amino acid 383. mRNA level in liver tissue is decreased and protein level is very low. (J:262204)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F9 Mutation:	8 strains or lines available

Original:	J:262204 Guan Y, et al., CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse. EMBO Mol Med. 2016 May;8(5):477-88
All:	1 reference(s)