Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Hoxd10em1Ddu
Name:	homeobox D10; endonuclease-mediated mutation 1, Denis Duboule
MGI ID:	MGI:6195701
Synonyms:	Hoxd10hd
Gene:	Hoxd10  Location: Chr2:74522268-74525449 bp, + strand  Genetic Position: Chr2, 44.13 cM
Alliance:	Hoxd10em1Ddu page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Starting with genomic DNA from the Del(2Hoxd1-Hoxd9)63Ddu allele, a 10 bp deletion (CCGACAGGCA) was created Using sgRNA 5'-AGAGCGTTAACCTCACCGAC,-3'. This deletion affects the coding region, introducing a frameshift and premature stop codon that replaces the last 34 amino-acids of the encoded peptide with 10 new amino-acids. This truncated peptide has a disrupted homeodomain with the third alpha-helix eliminated. (J:252916)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd10 Mutation:	15 strains or lines available

Original:	J:252916 Zakany J, et al., Control of growth and gut maturation by HoxD genes and the associated lncRNA Haglr. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9290-E9299
All:	1 reference(s)