Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Rapgef3tm1.1Ics
Name:	Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1.1, Mouse Clinical Institute
MGI ID:	MGI:6195641
Gene:	Rapgef3  Location: Chr15:97642651-97665853 bp, - strand  Genetic Position: Chr15, 53.74 cM
Alliance:	Rapgef3tm1.1Ics page

Germline Transmission:	Earliest citation of germline transmission: J:264168
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: A loxP and FRT flanked neo cassette was inserted in intron 6 and a loxP site was inserted in intron 10 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exons 7 - 10 (1.7 kb) floxed and a single FRT site upstream of the loxP site in intron 6. (J:264168)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rapgef3 Mutation:	45 strains or lines available

Original:	J:264168 Kopperud RK, et al., Increased microvascular permeability in mice lacking Epac1 (Rapgef3). Acta Physiol (Oxf). 2017 Feb;219(2):441-452
All:	1 reference(s)