Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Rapgef3tm1.2Flh
Name:	Rap guanine nucleotide exchange factor (GEF) 3; targeted mutation 1.2, Frank Lezoualc'h
MGI ID:	MGI:6188856
Gene:	Rapgef3  Location: Chr15:97642651-97665853 bp, - strand  Genetic Position: Chr15, 53.74 cM
Alliance:	Rapgef3tm1.2Flh page

Germline Transmission:	Earliest citation of germline transmission: J:230297
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A loxP site was inserted upstream of exon 8. An FRT-flanked neomycin resistance gene cassette and a second loxP site were inserted downstream of exon 15. Flp-mediated recombination removed the selection cassette and exons 8 through 15 were deleted through subsequent cre-mediated recombination. (J:230297)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rapgef3 Mutation:	45 strains or lines available

Original:	J:230297 Laurent AC, et al., Exchange protein directly activated by cAMP 1 promotes autophagy during cardiomyocyte hypertrophy. Cardiovasc Res. 2015 Jan 1;105(1):55-64
All:	4 reference(s)