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Lhx3tm1.3Gan
Targeted Allele Detail
Summary
Symbol: Lhx3tm1.3Gan
Name: LIM homeobox protein 3; targeted mutation 1.3, Lin Gan
MGI ID: MGI:6156086
Synonyms: Lhx3 null
Gene: Lhx3  Location: Chr2:26090224-26098261 bp, - strand  Genetic Position: Chr2, 18.44 cM, cytoband A2-C1
Alliance: Lhx3tm1.3Gan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:261409
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac or C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA FRT site, GFP, loxP site, neomycin resistance cassette, FRT and a loxP site were inserted upstream of exon 3 and a third loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neomycin and GFP. Cre-mediated recombination removed exons 3-5. (J:261409)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx3 Mutation:  25 strains or lines available
Notes
"Linearized Lhx3ckoGFP targeting construct was electroporated into C57BL/6J-129S6 hybrid embryonic stem cells (ESCs)." (J:261409)
References
Original:  J:261409 Xu M, et al., Generation and characterization of Lhx3(GFP) reporter knockin and Lhx3(loxP) conditional knockout mice. Genesis. 2018 Apr;56(4):e23098
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory