Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pou3f1tm2.1Mejr
Name:	POU domain, class 3, transcription factor 1; targeted mutation 2.1, Dies Meijer
MGI ID:	MGI:2387953
Synonyms:	Oct-6deltaSCE
Gene:	Pou3f1  Location: Chr4:124551439-124554448 bp, + strand  Genetic Position: Chr4, 57.86 cM
Alliance:	Pou3f1tm2.1Mejr page

Germline Transmission:	Earliest citation of germline transmission: J:78939
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Hypomorph, Modified regulatory region) Mutations:    Insertion, Intragenic deletion   Mutation details: The floxed puromycin selection cassette was removed from Pou3f1tm2Mejr by in vivo cre mediated excision, producing a hypomorphic allele lacking the 4.3 kb Schwann cell specific enhancer element. While protein was undetected by immunohistochemical analysis of Schwann cell nuclei isolated from homozygous mutant mice, low levels were detected by Western blot analysis. Protein expression was unaffected in the brainstem. (J:78939)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f1 Mutation:	14 strains or lines available

Original:	J:78939 Ghazvini M, et al., A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration. EMBO J. 2002 Sep 2;21(17):4612-20
All:	4 reference(s)