Rfx1tm1.1Smoc
Targeted Allele Detail
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Symbol: |
Rfx1tm1.1Smoc |
Name: |
regulatory factor X, 1 (influences HLA class II expression); targeted mutation 1.1, Shanghai Model Organisms Center |
MGI ID: |
MGI:6143866 |
Synonyms: |
Rfx1f |
Gene: |
Rfx1 Location: Chr8:84793463-84823621 bp, + strand Genetic Position: Chr8, 40.28 cM
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Alliance: |
Rfx1tm1.1Smoc page
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Germline Transmission: |
Earliest citation of germline transmission:
J:257972
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Parent Cell Line: |
JM8A3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: A FRT-flanked PGK-neomycin cassette and a loxP site were inserted upstream of exon 3 and a second loxP site downstream of exon 4. Flp-mediated recombination removed the selection cassette, leaving exons 3-4 floxed.
(J:257972)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rfx1 Mutation: |
46 strains or lines available
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Original: |
J:257972 Zhao M, et al., IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation. Nat Commun. 2018 Feb 8;9(1):583 |
All: |
2 reference(s) |
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