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Rfx1tm1.1Smoc
Targeted Allele Detail
Summary
Symbol: Rfx1tm1.1Smoc
Name: regulatory factor X, 1 (influences HLA class II expression); targeted mutation 1.1, Shanghai Model Organisms Center
MGI ID: MGI:6143866
Synonyms: Rfx1f
Gene: Rfx1  Location: Chr8:84793463-84823621 bp, + strand  Genetic Position: Chr8, 40.28 cM
Alliance: Rfx1tm1.1Smoc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:257972
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA FRT-flanked PGK-neomycin cassette and a loxP site were inserted upstream of exon 3 and a second loxP site downstream of exon 4. Flp-mediated recombination removed the selection cassette, leaving exons 3-4 floxed. (J:257972)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rfx1 Mutation:  46 strains or lines available
References
Original:  J:257972 Zhao M, et al., IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation. Nat Commun. 2018 Feb 8;9(1):583
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory