Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Pik3c3tm1.1Arte
Name:	phosphatidylinositol 3-kinase catalytic subunit type 3; targeted mutation 1.1, TaconicArtemis
MGI ID:	MGI:6115471
Synonyms:	Vps34D761A
Gene:	Pik3c3  Location: Chr18:30405800-30481179 bp, + strand  Genetic Position: Chr18, 17.41 cM
Alliance:	Pik3c3tm1.1Arte page

Germline Transmission:	Earliest citation of germline transmission: J:255862
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Not Specified) Mutation:    Undefined   Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 21. An F3-flanked puromycin resistance cassette with a 3' loxP site was inserted downstream of exon 21. Exon 22 was replaced with a modified exon in which a nucleotide substitution results in the amino acid substitution of alanine for aspartic acid at position 761 (D761A). Flp-mediated recombination removed both selection cassette. (J:255862)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pik3c3 Mutation:	45 strains or lines available

Original:	J:255862 Bilanges B, et al., Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism. Nat Commun. 2017 Nov 27;8(1):1804
All:	1 reference(s)