Summary | Transgene origin | Transgene description | Find Mice (IMSR) | References

Symbol:	Tg(Myh6-Pparg)#Ijg
Name:	transgene insertion, Ira J Goldberg
MGI ID:	MGI:6099068
Synonyms:	MHC-PPARgamma1
Transgene:	Tg(Myh6-Pparg)#Ijg  Location: unknown
Alliance:	Tg(Myh6-Pparg)#Ijg page

Strain of Origin:

(CBA x C57BL/6)F1

Transgene Type:    Transgenic (Inserted expressed sequence, Modified isoform(s)) Mutation:    Insertion   Tg(Myh6-Pparg)#Ijg expresses 1 gene Transgene expresses: Organism Expressed Gene Note mouse Pparg (MGI:97747) Gamma1 isoform of Pparg   Mutation details: The transgene insert comprises the following: 5.4 kb of genomic sequence containing the mouse myosin heavy chain alpha (cardiac) promoter and exons 1-3, a cDNA for the gamma1 isoform of the mouse Pparg gene and poly(A) features. This allele drives overexpression of the inserted gene in the heart, as shown by RT-PCR experiments. Two lines were used for furher study: a high expressing line and a low expressing line. (J:127393)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:127393 Son NH, et al., Cardiomyocyte expression of PPARgamma leads to cardiac dysfunction in mice. J Clin Invest. 2007 Oct;117(10):2791-801
All:	2 reference(s)