Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Gata1tm1.1Yey
Name:	GATA binding protein 1; targeted mutation 1.1, Y Yu
MGI ID:	MGI:6099055
Synonyms:	Gata1Yeym2
Gene:	Gata1  Location: ChrX:7825504-7842844 bp, - strand  Genetic Position: ChrX, 3.59 cM, cytoband A2
Alliance:	Gata1tm1.1Yey page

Germline Transmission:	Earliest citation of germline transmission: J:257058
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Hypomorph) Mutation:    Intergenic deletion   Mutation details: The targeting vector is designed to replace exon 2 with a loxP-flanked neomycin resistance (neo) cassette. The neo cassette was deleted by transiently transfection of an expression vector of Cre recombinase in the ES cells. The resulting protein GATAs is truncated. (J:257058)

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gata1 Mutation:	44 strains or lines available

Original:	J:257058 Liu C, et al., Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors. Oncotarget. 2018 Jan 12;9(4):4773-4786
All:	1 reference(s)