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Sphk1tm1Geno
Targeted Allele Detail
Summary
Symbol: Sphk1tm1Geno
Name: sphingosine kinase 1; targeted mutation 1, Genoway
MGI ID: MGI:6095627
Gene: Sphk1  Location: Chr11:116421751-116427501 bp, + strand  Genetic Position: Chr11, 81.42 cM, cytoband E2
Alliance: Sphk1tm1Geno page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:248572
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    A neomycin resistance cassette replaced exons 3 through 6. (J:248572)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sphk1 Mutation:  30 strains or lines available
Notes
Originally published in Pushparaj PN et al. "Sphingosine kinase1 is pivotal for Fc{epsilon}RI-mediated mast cell signaling and functional responses in vitro and in vivo" (J Immunol. 2012 Sep 15;189(6):3262) but later retracted (see retraction PMID: 22956763 for more detail). The retraction did not impact the generation of the alleles performed by Genoway.
References
Original:  J:248572 Genoway, Generation of Sphk1 and Sphk2. 2017;
All:  5 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory