Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Esr2tm1.1(icre)Jako
Name:	estrogen receptor 2 (beta); targeted mutation 1.1, CheMyong Ko
MGI ID:	MGI:5907833
Synonyms:	Esr2-iCre
Gene:	Esr2  Location: Chr12:76167193-76224033 bp, - strand  Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
Alliance:	Esr2tm1.1(icre)Jako page

Germline Transmission:	Earliest citation of germline transmission: J:229096
Parent Cell Line:	PRX-B6N (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Recombinase) Mutation:    Insertion   Esr2tm1.1(icre)Jako expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Esr2 (MGI:109392)   Mutation details: A targeting vector containing iCre (codon-improved Cre recombinase), a polyadenylation sequence, and an FRT site flanked PGK-NEO cassette was inserted into the initiation codon site of exon 2 of the targeted gene. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:229096)

Activity:	Tissue activity of this recombinase allele
Driver:	Esr2 (mouse) Summary of all recombinase alleles driven by Esr2. Alliance mouse Esr2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esr2 Mutation:	32 strains or lines available

Original:	J:229096 Cacioppo JA, et al., Generation of an estrogen receptor beta-iCre knock-in mouse. Genesis. 2016 Jan;54(1):38-52
All:	4 reference(s)