Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acer2em1Mvw
Name:	alkaline ceramidase 2; endonuclease-mediated mutation 1, Jackson
MGI ID:	MGI:5883755
Gene:	Acer2  Location: Chr4:86792633-86853059 bp, + strand  Genetic Position: Chr4, 40.69 cM
Alliance:	Acer2em1Mvw page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: A 452bp deletion removed the entire exon 2 and a large portion of the adjacent intron and western blot analysis failed to detect ACER2 protein in homozygotes. (J:256650) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

2 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Acer2 Mutation:	41 strains or lines available

Original:	J:256650 Li F, et al., Alkaline ceramidase 2 is essential for the homeostasis of plasma sphingoid bases and their phosphates. FASEB J. 2018 Jun;32(6):3058-3069
All:	4 reference(s)