Nfatc1tm1Akpa
Targeted Allele Detail
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| Symbol: |
Nfatc1tm1Akpa |
| Name: |
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1; targeted mutation 1, Amiya Kumar Patra |
| MGI ID: |
MGI:5882714 |
| Synonyms: |
Nfatc1 P2fl |
| Gene: |
Nfatc1 Location: Chr18:80649420-80756286 bp, - strand Genetic Position: Chr18, 53.66 cM, cytoband E4
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| Alliance: |
Nfatc1tm1Akpa page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:239886
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Conditional ready, No functional change) |
| Mutation: |
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Insertion
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Mutation details: A loxP site, a neomycin resistance gene cassette and a second loxP site were inserted upstream of the alternative P2 promoter in intron 1. A third loxP site was inserted downstream of the promoter. This creates a conditional-ready isoform specific knock-out allele which, upon cre-mediated recombination, would abolish transcription of the betaA, betaB and betaC splice variants.
(J:239886)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Nfatc1 Mutation: |
47 strains or lines available
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| Original: |
J:239886 Klein-Hessling S, et al., A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development. Nat Commun. 2016 Jun 17;7:11841 |
| All: |
1 reference(s) |
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Analysis Tools
