Summary | Transgene origin | Transgene description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Tg(Prop1-icre)517Sac
Name:	transgene insertion 517, Sally A Camper
MGI ID:	MGI:5818681
Synonyms:	Prop1-cre, Tg(Prop1-cre)517Sac, Tg(Prop1-icre)1Sac
Transgene:	Tg(Prop1-icre)517Sac  Location: unknown
Alliance:	Tg(Prop1-icre)517Sac page

Strain of Origin:

C57BL/6J x (C57BL/6 x DBA/2)F1

Transgene Type:    Transgenic (Recombinase) Mutation:    Insertion   Tg(Prop1-icre)517Sac expression driven by 1 gene Transgene expression driven by: Organism Driver Gene Note mouse Prop1 (MGI:109330)   Mutation details: A BAC (RP23-479M11) containing the Prop1 gene was modified by inserting a cassette composed of the sequence encoding a mammalian codon usage optimized cre recombinase (icre), the bovine GH polyadenylation signal and an Frt-flanked kanamycin selection marker, into the exon 2 in frame. Flpe excision removed the kanamycin selection marker. The modified BAC was injected into pronuclei of fertilized oocytes to generate transgenic mice. Three lines, 432, 506, and 517 were genereted, and all 3 lines exhibit cre activity throughout the pituitary anterior lobe at 3 weeks of age. Line 517 was used for studies because it best reflected endogenous Prop1 expression. (J:233898)

Activity:	Tissue activity of this recombinase allele
Driver:	Prop1 (mouse) Summary of all recombinase alleles driven by Prop1. Comparative matrix view of recombinase activities Alliance mouse Prop1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available

Original:	J:233898 Davis SW, et al., All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors. Endocrinology. 2016 Apr;157(4):1385-96
All:	3 reference(s)