Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Tcf7tm1Hhx
Name:	transcription factor 7, T cell specific; targeted mutation 1, Hai-Hui Xue
MGI ID:	MGI:5805838
Synonyms:	p45-, Tcf7GFP
Gene:	Tcf7  Location: Chr11:52143198-52174158 bp, - strand  Genetic Position: Chr11, 31.86 cM
Alliance:	Tcf7tm1Hhx page

Germline Transmission:	Earliest citation of germline transmission: J:233391
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Conditional ready, Modified isoform(s), Reporter) Mutation:    Insertion   Mutation details: An FRT-flanked En2-SA-IRES-EGFP-polyA with a neomycin resistance cassette followed by a 3'loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Placement of the cassette interferes with the expression of the long (p45 and p42) isoforms but not the short (p33 and p30) isoforms. (J:233391)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tcf7 Mutation:	24 strains or lines available

Original:	J:233391 Yang Q, et al., TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nat Immunol. 2015 Oct;16(10):1044-50
All:	18 reference(s)