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Sox2tm1.1(cre/ERT2)Kinz
Targeted Allele Detail
Nomenclature
Symbol: Sox2tm1.1(cre/ERT2)Kinz
Name: SRY (sex determining region Y)-box 2; targeted mutation 1.1, Bernd Kinzel
MGI ID: MGI:5804019
Synonyms: Sox2-IRES-CreERT2
Gene: Sox2  Location: Chr3:34650405-34652461 bp, + strand  Genetic Position: Chr3, 16.93 cM, cytoband A2-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:234789
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsAn IRES-cre/ERT2 cassette followed by an rox-flanked neo selection cassette was inserted into the 3' UTR by homologous recombination. Mice were crossed to Dre-expressing mice to delete the rox-flanked neo cassette. (J:234789)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sox2     Summary of all recombinase alleles driven by Sox2. Comparative matrix view of recombinase activities
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox2 Mutation:  23 strains or lines available
References
Original:  J:234789 Riccardi S, et al., MiR-210 promotes sensory hair cell formation in the organ of corti. BMC Genomics. 2016;17:309
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/10/2020
MGI 6.16
The Jackson Laboratory