Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Dp(16App-Runx1)5Yah
Name:	duplication, Chr 16, Yann Herault 5
MGI ID:	MGI:5789045
Gene:	Dp(16App-Runx1)5Yah  Location: unknown  Genetic Position: Chr16, Syntenic

Strain of Origin:

(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Not Specified) Mutation:    Duplication   Mutation details: Cre recombinase-induced recombination between a loxP site at the App locus (Apptm1Yah) and a loxP site in Runx1 (Runx1tm1Yg) on the oposite Chr 16 homolog (in trans) resulted in duplication of the intervening chromosomal segment. To achieve this, a male mouse carrying Runx1tm1Yg was mated to a female bearing Hprttm1(CAG-cre)Mnn, and a female offspring with both targeted alleles was bred with a male carrying Apptm1Yah. A daughter carrying all three modifications, in whose oocytes recombination occurred, was mated to C57BL/6 males to obtain offspring with the duplication. (J:82809)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dp(16App-Runx1)5Yah Mutation:	1 strain or line available

Original:	J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013;
All:	1 reference(s)