Runx1tm9Spe
Targeted Allele Detail
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| Symbol: |
Runx1tm9Spe |
| Name: |
runt related transcription factor 1; targeted mutation 9, Nancy A Speck |
| MGI ID: |
MGI:5788255 |
| Synonyms: |
Runx1L148A, Runx1tm1Hdrs |
| Gene: |
Runx1 Location: Chr16:92398354-92622962 bp, - strand Genetic Position: Chr16, 53.7 cM
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| Alliance: |
Runx1tm9Spe page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:233274
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Hypomorph) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exon 4 was replaced with a modified one with the amino acid substitution of alanine for lysine at position 148 (L148A). A floxed neomycin resistance cassette was inserted downstream of the modified exon 4.
(J:233274)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Runx1 Mutation: |
35 strains or lines available
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| Original: |
J:233274 Soung do Y, et al., Runx1 dose-dependently regulates endochondral ossification during skeletal development and fracture healing. J Bone Miner Res. 2012 Jul;27(7):1585-97 |
| All: |
1 reference(s) |
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Analysis Tools
