Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Pgrtm1.1Nlw
Name:	progesterone receptor; targeted mutation 1.1, Nancy L Weigel
MGI ID:	MGI:5707260
Synonyms:	PR S191A
Gene:	Pgr  Location: Chr9:8899834-8968612 bp, + strand  Genetic Position: Chr9, 2.46 cM
Alliance:	Pgrtm1.1Nlw page

Germline Transmission:	Earliest citation of germline transmission: J:218283
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Hypomorph, Modified regulatory region) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A Ser191 phosphorylation site in exon 1 was mutated to alanine and an FRT flaked neo cassette was inserted in intron 1 via homologous recombination. Flp mediated recombination removed the neo cassette. Immunoblot analysis indicates that protein expression is similar to that of the wild-type allele. Chromatin immunoprecipitation analysis indicates reduced binding activity to some enhancers. (J:218283)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pgr Mutation:	73 strains or lines available

Original:	J:218283 Grimm SL, et al., A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo. Mol Endocrinol. 2014 Dec;28(12):2025-37
All:	1 reference(s)