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Stat1tm1.1Bstr
Targeted Allele Detail
Nomenclature
Symbol: Stat1tm1.1Bstr
Name: signal transducer and activator of transcription 1; targeted mutation 1.1, Birgit Strobl
MGI ID: MGI:5705230
Synonyms: Stat1alpha
Gene: Stat1  Location: Chr1:52119440-52161865 bp, + strand  Genetic Position: Chr1, 26.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:221627
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutation:    Insertion
 
Mutation detailsThe targeting vector introduced into exon 19 the cDNA for the terminal portion of the alpha isoform, a human beta-globin splice and floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. (J:221627)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stat1 Mutation:  24 strains or lines available
References
Original:  J:221627 Semper C, et al., STAT1beta is not dominant negative and is capable of contributing to gamma interferon-dependent innate immunity. Mol Cell Biol. 2014 Jun;34(12):2235-48
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory