Myod1<tm2(Myf5)Mrc> Targeted Allele Detail MGI Mouse (MGI:5704215)

Myod1^tm2(Myf5)Mrc
Targeted Allele Detail

Summary

Symbol:	Myod1^tm2(Myf5)Mrc
Name:	myogenic differentiation 1; targeted mutation 2, Mario R Capecchi
MGI ID:	MGI:5704215
Synonyms:	MyoD^Myf5ki
Gene:	Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
Alliance:	Myod1^tm2(Myf5)Mrc page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:217688
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Mutation
description

Allele Type:

Targeted (Inserted expressed sequence)

Mutations:

Insertion, Intragenic deletion

Myod1^tm2(Myf5)Mrc expresses 1 gene

Mutation details: The Myf5 cDNA, FRT site, an IRES sequence, an EGFP reporter gene and an FRT site replaced 451 bp downstream of the translation initation site. (J:217688)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Myod1 Mutation:	23 strains or lines available

Notes

This allele fails to rescue myogenesis in Myf5 deficient mice.

References

Original:	J:217688 Haldar M, et al., Response: Contributions of the Myf5-independent lineage to myogenesis. Dev Cell. 2014 Dec 8;31(5):539-41
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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