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Targeted Allele Detail
Symbol: Dp(16Dyrk1a-B3galt5)5TybEmcf
Name: duplication, Chr 16, Victor Tybulewicz and Elizabeth M C Fisher 5
MGI ID: MGI:5703806
Synonyms: Dp(16)5TybEmcf, Dp5Tyb
Gene: Dp(16Dyrk1a-B3galt5)5TybEmcf  Location: unknown  Genetic Position: Chr16, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:227899
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted
Mutations:    Duplication, Insertion
  Dp(16Dyrk1a-B3galt5)5TybEmcf involves 38 genes/genome features (Gm15317, Gm15341, Gm22745 ...) View all
Mutation detailsMICER vectors MHPP432c09 (16:94538615-16:94546849 Mb; mouse assembly GRCm38/mm10) located between Dscr3 and Dyrk1a and MHPN235b18 (16:96327324-16:96331804 Mb) located between B3galt5 and Igsf5 were subjected to cre-mediated recombination to duplicate the sequence flanked by loxP sites. (J:227899)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dp(16Dyrk1a-B3galt5)5TybEmcf Mutation:  1 strain or line available
Original:  J:227899 Lana-Elola E, et al., Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel. Elife. 2016 Jan 14;5:e11614
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.19
The Jackson Laboratory