Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Fn1tm1Ref
Name:	fibronectin 1; targeted mutation 1, Reinhard Fassler
MGI ID:	MGI:2387457
Synonyms:	Fn(fl), FNflox
Gene:	Fn1  Location: Chr1:71624679-71692359 bp, - strand  Genetic Position: Chr1, 36.05 cM, cytoband C1-C5
Alliance:	Fn1tm1Ref page

Germline Transmission:	Earliest citation of germline transmission: J:67961
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exon 1 was flanked by loxP sites inserted into the 5' untranslated region and intron 1. The presence of the loxP sites were shown to have no effect on expression, as the levels of mRNA in liver and of protein in plasma, liver, heart, kidney were found to be normal by Northern and Western blot analyses. (J:67961)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fn1 Mutation:	129 strains or lines available

Original:	J:67961 Sakai T, et al., Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med. 2001 Mar;7(3):324-30
All:	29 reference(s)