Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Htr1atm1Rhn
Name:	5-hydroxytryptamine (serotonin) receptor 1A; targeted mutation 1, Rene Hen
MGI ID:	MGI:2387407
Synonyms:	5-HT1A
Gene:	Htr1a  Location: Chr13:105580147-105584630 bp, + strand  Genetic Position: Chr13, 56.92 cM
Alliance:	Htr1atm1Rhn page

Germline Transmission:	Earliest citation of germline transmission: J:51280
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The endogenous locus was disrupted by the insertion of a neomycin selection cassette downstream of sequence encoding the third transmembrane domain. Homozygous mutant mice were shown to lack functional receptors via autoradiography studies of brain sections. (J:51280)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Htr1a Mutation:	26 strains or lines available

Original:	J:51280 Ramboz S, et al., Serotonin receptor 1A knockout: an animal model of anxiety-related disorder [see comments]. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14476-81
All:	32 reference(s)