Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Agltm1Geno
Name:	amylo-1,6-glucosidase, 4-alpha-glucanotransferase; targeted mutation 1, Genoway
MGI ID:	MGI:5661387
Gene:	Agl  Location: Chr3:116533648-116601815 bp, - strand  Genetic Position: Chr3, 50.47 cM
Alliance:	Agltm1Geno page

Germline Transmission:	Earliest citation of germline transmission: J:218471
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 32-34 (coding for the last 114 amino acids) were replaced with a loxP flanked neomycin resistance cassette. This deletes the carboxy terminus, including the glucosidase and glycogen-binding domains. Western blot analysis confirmed absence of protein in all tissues analyzed. (J:218471)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agl Mutation:	80 strains or lines available

Original:	J:218471 Pagliarani S, et al., Glycogen storage disease type III: A novel Agl knockout mouse model. Biochim Biophys Acta. 2014 Nov;1842(11):2318-28
All:	2 reference(s)