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Ccna2tm1.1Kald
Targeted Allele Detail
Summary
Symbol: Ccna2tm1.1Kald
Name: cyclin A2; targeted mutation 1.1, Philipp Kaldis
MGI ID: MGI:5637531
Synonyms: A2flox
Gene: Ccna2  Location: Chr3:36619014-36626299 bp, - strand  Genetic Position: Chr3, 17.67 cM
Alliance: Ccna2tm1.1Kald page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212546
Parent Cell Line:  S1B6 (ES Cell)
Strain of Origin:  129S1/SvImJ or C57BL/6J
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:212546)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccna2 Mutation:  15 strains or lines available
References
Original:  J:212546 Gopinathan L, et al., Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. Cancer Res. 2014 Jul 15;74(14):3870-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory