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Hcrtr1tm1.1Ava
Targeted Allele Detail
Nomenclature
Symbol: Hcrtr1tm1.1Ava
Name: hypocretin (orexin) receptor 1; targeted mutation 1.1, Anne Vassalli
MGI ID: MGI:5637400
Synonyms: Hcrtr1flox
Gene: Hcrtr1  Location: Chr4:130024010-130033152 bp, - strand  Genetic Position: Chr4, 63.43 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:226158
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready, Reporter)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted at the start codon in exon 3. A loxP site, GFP reporter gene, polyadenylation sequence, and FRT-flanked neomycin resistance cassette were inserted into intron 4. Flp-mediated recombination removed the selection cassette. (J:226158)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hcrtr1 Mutation:  22 strains or lines available
References
Original:  J:226158 Vassalli A, et al., Did hypocretin receptor 2 autoantibodies cause narcolepsy with hypocretin deficiency in Pandemrix-vaccinated children? Comment on Antibodies to influenza nucleoprotein cross react with human hypocretin receptor 2. Sci Transl Med. 2015;7:314le2
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory