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Fostm1Mxu
Targeted Allele Detail
Nomenclature
Symbol: Fostm1Mxu
Name: FBJ osteosarcoma oncogene; targeted mutation 1, Ming Xu
MGI ID: MGI:2387304
Synonyms: f/fc-fos
Gene: Fos  Location: Chr12:85473901-85477269 bp, + strand  Genetic Position: Chr12, 39.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75813
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA region containing sequence encoding the DNA-binding and leucine zipper domains and a downstream neo transgene was flanked by single loxP sites. In situ hybridization and immunostaining indicated that the loxP sites did not interfere with transcription or translation. (J:75813)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fos Mutation:  28 strains or lines available
References
Original:  J:75813 Zhang J, et al., c-fos regulates neuronal excitability and survival. Nat Genet. 2002 Apr;30(4):416-20
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory