Summary | Mutation origin | Mutation description | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Apctm1Hsa
Name:	APC, WNT signaling pathway regulator; targeted mutation 1, Hitoshi Sasai
MGI ID:	MGI:2387050
Synonyms:	Apcdelta474
Gene:	Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance:	Apctm1Hsa page

Germline Transmission:	Earliest citation of germline transmission: J:61978
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Duplication, Insertion   Apctm1Hsa involves 1 genes/genome features (Apc) View all   Mutation details: The gene was disrupted at exon 9 by insertion of a neo cassette and exons 10, 7, 8, and 9. The insertion and duplication results in a frameshift and premature translation termination. The mutant allele was confirmed by RT-PCR analysis. (J:61978)

View phenotypes and curated references for all genotypes (concatenated display).

List all tumor models in MMHCdb carrying Apctm1Hsa

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	154 strains or lines available

Original:	J:61978 Sasai H, et al., Suppression of polypogenesis in a new mouse strain with a truncated Apc(Delta474) by a novel COX-2 inhibitor, JTE-522. Carcinogenesis. 2000 May;21(5):953-8
All:	3 reference(s)