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Myo10m1J
Spontaneous Allele Detail
Nomenclature
Symbol: Myo10m1J
Name: myosin X; mutation 1 Jackson
MGI ID: MGI:5578506
Gene: Myo10  Location: Chr15:25622550-25813673 bp, + strand  Genetic Position: Chr15, 9.36 cM, cytoband C
Mutation
origin
Strain of Origin:  B6.129S2-Cd4tm1Mak/J
Mutation
description
Allele Type:    Spontaneous (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis is a spontaneous eight nucleotide (CGACGAGT) deletion in Chromosome 15 position 25,781,267 bp to 25,781,274 bp (GRCm38). The deletion disrupts exon 25 and produces a frame shift expected to truncate the full-length and all three headless transcripts following aa 948. Immunoblot of whole brain lysates from 1-month-old mutant mice revealed combined deletion of the full-length and headless forms, confirming complete loss of encoded protein. (J:222308, J:256438)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Myo10 Mutation:  566 strains or lines available
References
Original:  J:214794 Karst SY, et al., A spontaneous mutation in mouse Myo10. MGI Direct Data Submission. 2014;
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory