Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kmotm1Pjmi
Name:	kynurenine 3-monooxygenase; targeted mutation 1, Paul J Muchowski
MGI ID:	MGI:5569394
Synonyms:	Kmoflox (ex5)
Gene:	Kmo  Location: Chr1:175459759-175488419 bp, + strand  Genetic Position: Chr1, 81.6 cM
Alliance:	Kmotm1Pjmi page

Germline Transmission:	Earliest citation of germline transmission: J:207199
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6J

Allele Type:    Targeted (Hypomorph) Mutation:    Insertion   Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. Authors state that this allele produces a product that is hypomorphic for kynurenine 3-monooxygenase activity. (J:207199)

Generation of the Kmotm1Pjmi allele

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmo Mutation:	36 strains or lines available

Original:	J:207199 Giorgini F, et al., Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain. J Biol Chem. 2013 Dec 20;288(51):36554-66
All:	1 reference(s)