Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm2.1(SORL1*)Tew
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 2.1, Thomas E Willnow
MGI ID:	MGI:5553052
Synonyms:	Rosa26TgSORLAgga, SORLAacidic
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm2.1(SORL1*)Tew page

Germline Transmission:	Earliest citation of germline transmission: J:205418
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence) Mutation:    Insertion   Gt(ROSA)26Sortm2.1(SORL1*)Tew expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human SORL1 (6653) Sorl1  (MGI:1202296)   Mutation details: The targeting construct inserted into the locus the human cDNA lacking the acidic cluster motif preceded by a splice acceptor and floxed neomycin resistance cassette and followed by a polyadenylation sequence. Cre-mediated recombination removed the resistance cassette and allowed for expression of the human cDNA. (J:205418)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	944 strains or lines available

Original:	J:205418 Burgert T, et al., SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol. 2013 Nov;33(21):4308-20
All:	2 reference(s)