Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Wnt2tm2.1(cre/ERT2)Eem
Name:	wingless-type MMTV integration site family, member 2; targeted mutation 2.1, Edward E Morrisey
MGI ID:	MGI:5544574
Synonyms:	Wnt2creERT2
Gene:	Wnt2  Location: Chr6:17988939-18030584 bp, - strand  Genetic Position: Chr6, 8.08 cM, cytoband A2-A3.1
Alliance:	Wnt2tm2.1(cre/ERT2)Eem page

Germline Transmission:	Earliest citation of germline transmission: J:204743
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Wnt2tm2.1(cre/ERT2)Eem expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Wnt2 (MGI:98954)   Mutation details: A targeting construct was designed so that homologous recombination in ES cells inserted the cre/ERT2 fusion sequence and a neo selection marker after the ATG start codon in exon 1 (replacing exon 1). After establishing germline transmission, Flp-mediated excision removed the neo cassette. (J:204743)

Activity:	Tissue activity of this recombinase allele
Driver:	Wnt2 (mouse) Summary of all recombinase alleles driven by Wnt2. Alliance mouse Wnt2 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wnt2 Mutation:	26 strains or lines available

Original:	J:204743 Peng T, et al., Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29;500(7464):589-92
All:	2 reference(s)