Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte
Targeted Allele Detail
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Symbol: |
Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 4, TaconicArtemis |
MGI ID: |
MGI:5521554 |
Synonyms: |
Ezh2-tetKDA |
Gene: |
Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
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Alliance: |
Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte page
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Germline Transmission: |
Earliest citation of germline transmission:
J:202724
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6
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Allele Type: |
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Targeted (Inducible, Knockdown) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Gt(ROSA)26Sortm4(H1/tetO-RNAi:Ezh2)Arte involves 1 genes/genome features (Ezh2)
View all
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Mutation details: A short hairpin RNA directed against exon 8 of Ezh2 was targeted into the locus. The shRNA sequence is under the regulation of the H1/tetO operator fusion promoter and a codon-optimized tet repressor (itetR) driven by the CAGGS promoter.
(J:202724)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gt(ROSA)26Sor Mutation: |
944 strains or lines available
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Original: |
J:202724 Michalak EM, et al., Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool. Stem Cells. 2013 Sep;31(9):1910-20 |
All: |
1 reference(s) |
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