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Gt(ROSA)26Sortm1(Gli2)Jmao
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(Gli2)Jmao
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Junhao Mao
MGI ID: MGI:5518625
Synonyms: R26Gli2
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(Gli2)Jmao page
Gli2 expression, but not Gli3 de-repression, rescues intestinal phenotypes in Smotm2Amc/Smotm2Amc Nkx3-2tm1(cre)Wez/Nkx3-2+ embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:199664
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(Gli2)Jmao expresses 1 gene
 
Mutation detailsThe C-terminally FLAG-tagged cDNA preceded by a floxed neomycin resistance and STOP cassette was inserted into the locus. (J:199664)
Generation of the Gt(ROSA)26Sortm1(Gli2)Jmao allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  942 strains or lines available
References
Original:  J:199664 Huang H, et al., Specific requirement of Gli transcription factors in Hedgehog-mediated intestinal development. J Biol Chem. 2013 Jun 14;288(24):17589-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory