Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Lmnb1tm1.2Sgy
Name:	lamin B1; targeted mutation 1.2, Stephen G Young
MGI ID:	MGI:5517590
Gene:	Lmnb1  Location: Chr18:56840885-56886496 bp, + strand  Genetic Position: Chr18, 30.84 cM
Alliance:	Lmnb1tm1.2Sgy page

Germline Transmission:	Earliest citation of germline transmission: J:197315
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked beta-geo cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Subsequent cre expresssion resulted in germline excision of exon 2 and the selection cassette. (J:174963, J:197315)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lmnb1 Mutation:	38 strains or lines available

Original:	J:197315 Jung HJ, et al., Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration. Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1923-32
All:	3 reference(s)