Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Kltm1.2Tel
Name:	klotho; targeted mutation 1.2, Tobias E Larsson
MGI ID:	MGI:5515329
Synonyms:	beta-KL-
Gene:	Kl  Location: Chr5:150876072-150917282 bp, + strand  Genetic Position: Chr5, 89.77 cM, cytoband G3
Alliance:	Kltm1.2Tel page

Germline Transmission:	Earliest citation of germline transmission: J:201719
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the neomycin resistance cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. Western blot analysis confirmed the absence of protein expression in the kidney. (J:201719)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kl Mutation:	53 strains or lines available

Original:	J:201719 Olauson H, et al., Targeted deletion of Klotho in kidney distal tubule disrupts mineral metabolism. J Am Soc Nephrol. 2012 Oct;23(10):1641-51
All:	4 reference(s)