Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gt(ROSA)26Sortm3(tetO-Mir193)Arte
Name:	gene trap ROSA 26, Philippe Soriano; targeted mutation 3, TaconicArtemis
MGI ID:	MGI:5512655
Gene:	Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance:	Gt(ROSA)26Sortm3(tetO-Mir193)Arte page

Germline Transmission:	Earliest citation of germline transmission: J:197989
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129 and C57BL/6

Allele Type:    Targeted (Inducible, Inserted expressed sequence, RMCE-ready) Inducer:    doxycycline/tetracycline Mutation:    Insertion   Gt(ROSA)26Sortm3(tetO-Mir193)Arte expresses 1 gene Knock-in expresses: Organism Expressed Gene Note mouse Mir193a (MGI:2676857)   Mutation details: RMCE introduced into the locus a tetracycline responsive promoter driving inducible expression of the short hairpin encoding Mir193 followed by a codon optimized tetracycline repressor. (J:197989)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:	942 strains or lines available

Original:	J:197989 Gebeshuber CA, et al., Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nat Med. 2013 Apr;19(4):481-7
All:	2 reference(s)