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Esrratm1.1Ics
Targeted Allele Detail
Summary
Symbol: Esrratm1.1Ics
Name: estrogen related receptor, alpha; targeted mutation 1.1, Mouse Clinical Institute
MGI ID: MGI:5496789
Synonyms: ERRalphafl
Gene: Esrra  Location: Chr19:6888345-6899182 bp, - strand  Genetic Position: Chr19, 5.08 cM
Alliance: Esrratm1.1Ics page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:195925
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    Exon 2 was floxed. Flp-mediated recombination removed the FRT-flanked selection cassette. (J:195925)
Generation of the conditional Esrratm1.1Ics allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Esrra Mutation:  25 strains or lines available
References
Original:  J:195925 Gallet M, et al., Repression of osteoblast maturation by ERRalpha accounts for bone loss induced by estrogen deficiency. PLoS One. 2013;8(1):e54837
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory