Rbbp8tm2Thl
Targeted Allele Detail
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| Symbol: |
Rbbp8tm2Thl |
| Name: |
retinoblastoma binding protein 8, endonuclease; targeted mutation 2, Thomas Ludwig |
| MGI ID: |
MGI:5494423 |
| Synonyms: |
CtipS326A-neo |
| Gene: |
Rbbp8 Location: Chr18:11766333-11876264 bp, + strand Genetic Position: Chr18, 5.85 cM
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| Alliance: |
Rbbp8tm2Thl page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:197743
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
129
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| Allele Type: |
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Targeted (Not Applicable) |
| Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exon 11 was replaced with a modified exon 11 in which nucleotide substitutions (TCT to GCA) result in the amino acid substitution of alanine for serine at position 326 (S326A). Additional nucleotide substitutions also introduce an Afel restriction site into the exon.
(J:197743)
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Generation of the Rbbp8tm2Thl and Rbbp8tm2.1Thl alleles |
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Rbbp8 Mutation: |
51 strains or lines available
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| Original: |
J:197743 Reczek CR, et al., The interaction between CtIP and BRCA1 is not essential for resection-mediated DNA repair or tumor suppression. J Cell Biol. 2013 May 27;201(5):693-707 |
| All: |
1 reference(s) |
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Analysis Tools
